This is a list of unnumbered trans-Neptunian objects (TNOs) first observed since 1993 and grouped by the year of principal provisional designation.The data is sourced from the Minor Planet Center's (MPC) List of Trans Neptunian Objects and List Of Centaurs and Scattered-Disk Objects. Published 26 April 2002 • Journal of Physics: Condensed Matter, Volume 14, Number 18. Oxford 202 142. Thornton J and Force R K 1991 Appl. Aisyiyah Jenie et al 2016 Pharmaceutical Research.

Received 8 April 2002; Accepted 4 September 2002 Introduction SnRK1 ( SNF1‐ Related Protein Kinase‐1) is a plant protein kinase with a catalytic domain similar to that of SNF1 ( Sucrose Non‐ fermenting‐1) of yeast and AMPK ( AMP‐activated protein kinase) of animals. The SNF1 family of protein kinases are a distinct group within the protein kinase superfamily, but are closely related to the calcium‐dependent protein kinase (CDPK) group, which includes the animal calmodulin‐dependent protein kinases and the plant calmodulin‐like domain protein kinases (). SNF1 () is activated in response to low cellular glucose levels and is required for the derepression of a battery of genes that are repressed by glucose (;; ).

It also directly modulates the phosphorylation state of a number of metabolic enzymes, including acetyl‐CoA carboxylase () and glycogen synthase (), and is required for the arrest of growth and the cell cycle under conditions of glucose deprivation (). AMPK is activated by AMP (, 1989) and by phosphorylation by an upstream protein kinase (AMP‐activated protein kinase kinase (AMPKK)) (). Activation of AMPK by AMP is antagonized by high (mM) concentrations of ATP and a high AMP:ATP ratio is symptomatic of low cellular energy levels. For this reason, AMPK has been likened to a cellular fuel gauge ().

When activated, it acts to conserve ATP by phosphorylating and inactivating regulatory enzymes of ATP‐consuming, anabolic pathways such as acetyl‐CoA carboxylase (fatty acid synthesis) (, 1992) and HMG‐CoA reductase (sterol/isoprenoid synthesis) (; ). The SnRK gene family The first plant SnRK1 sequence to be reported was a cDNA isolated from a rye endosperm cDNA library (). It encoded a 57.7 kDa protein of 502 amino acid residues showing 48% amino acid sequence identity with SNF1 and AMPK, rising to 62–64% amino acid sequence identity in the kinase catalytic domain.

SnRK1 genes have since been identified and characterized in many plant species (reviewed by ). They are present in small to medium‐sized gene families, comprising, for example, three members in arabidopsis and 10–20 in barley. The SnRK1 gene family of cereals can be subdivided further into two groups, SnRK1a and SnRK1b, on the basis of amino acid sequence similarity and expression patterns (). SnRK1a is expressed throughout the plant and is more closely related to SnRK1 from dicotyledonous plants. SnRK1b is expressed at the highest levels in the seed, although low levels of expression can be detected elsewhere, and is only present in monocotyledonous plants.